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The Applications of Hyberspectral Imaging Techniques in Online Quality Control of Medicines

在生產(chǎn)過(guò)程中，使用高光譜成像技術(shù)可以對(duì)藥品生產(chǎn)進(jìn)行實(shí)時(shí)監(jiān)控。對(duì)于大批量的醫(yī)藥品生產(chǎn)，比如透皮貼劑，藥片以及混合藥物來(lái)說(shuō)，高光譜成像技術(shù)是一種非接觸式、無(wú)損的、可以在線分析的理想工具。一臺(tái)推掃型光譜相機(jī)架設(shè)在生產(chǎn)線上，在生產(chǎn)的過(guò)程中對(duì)移動(dòng)的產(chǎn)品進(jìn)行成像，通過(guò)同時(shí)捕獲光譜維和空間維的信息，將監(jiān)測(cè)對(duì)象中不合規(guī)范的化學(xué)成分，有效成分分布不均勻以及不符合要求的情況通過(guò)特征光譜識(shí)別出來(lái)。對(duì)于很多醫(yī)藥生產(chǎn)來(lái)說(shuō)，有效成分按照配方的要求能夠在空間上正確的分布對(duì)于藥品達(dá)到理想的效果具有重要的意義。相比于批量生產(chǎn)，離線分析方法而言，在連續(xù)型生產(chǎn)過(guò)程，實(shí)時(shí)的分析出不合格的產(chǎn)品能夠有效降低生產(chǎn)成本。通過(guò)控制那些可能引起不合格產(chǎn)品的因素，高光譜技術(shù)能夠?yàn)檫^(guò)程控制提供技術(shù)規(guī)范。

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